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mananiso

mechanism of action of modafinil

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Does it act as alpha adrenergic agonist or by release of dopamine ?

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Modafinil has shown the ability to increase HA, NE, 5-HT, and DA levels in the brain (Ferraro et al 2000; de Saint Hilaire et al 2001; Ferraro et al 2002.

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Modafinil has shown the ability to increase HA, NE, 5-HT, and DA levels in the brain (Ferraro et al 2000; de Saint Hilaire et al 2001; Ferraro et al 2002.

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Bermingham says it is alphsa adrenergic agonist, and ibthink somm says it stimulates release ofvdop and NA ! any way do u have a reference for this

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yburaj
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Posted 09 Apr 2013 - 21:16

dopamine reuptake inhibitor

 

 

Modafinil is not a direct- or indirect-acting dopamine receptor agonist. However, in vitro, 
modafinil binds to the dopamine transporter and inhibits dopamine reuptake. This activity has 
been associated in vivo with increased extracellular dopamine levels in some brain regions of 
animals. In genetically engineered mice lacking the dopamine transporter (DAT), modafinil 
lacked wake-promoting activity, suggesting that this activity was DAT-dependent. However, the 
wake-promoting effects of modafinil, unlike those of amphetamine, were not antagonized by the 
dopamine receptor antagonist haloperidol in rats. In addition, alpha-methyl-p-tyrosine, a 
dopamine synthesis inhibitor, blocks the action of amphetamine, but does not block locomotor 
 
 
 
activity induced by modafinil.

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