Posted April 13, 2013 Does it act as alpha adrenergic agonist or by release of dopamine ? Share this post Link to post Share on other sites
Posted April 13, 2013 Modafinil has shown the ability to increase HA, NE, 5-HT, and DA levels in the brain (Ferraro et al 2000; de Saint Hilaire et al 2001; Ferraro et al 2002. Share this post Link to post Share on other sites
Posted April 13, 2013 Modafinil has shown the ability to increase HA, NE, 5-HT, and DA levels in the brain (Ferraro et al 2000; de Saint Hilaire et al 2001; Ferraro et al 2002. Share this post Link to post Share on other sites
Posted April 13, 2013 dopamine reuptake inhibitor 1 person likes this Share this post Link to post Share on other sites
Posted April 13, 2013 Bermingham says it is alphsa adrenergic agonist, and ibthink somm says it stimulates release ofvdop and NA ! any way do u have a reference for this Share this post Link to post Share on other sites
Posted April 13, 2013 yburaj Members 101 posts Posted 09 Apr 2013 - 21:16 dopamine reuptake inhibitor Modafinil is not a direct- or indirect-acting dopamine receptor agonist. However, in vitro, modafinil binds to the dopamine transporter and inhibits dopamine reuptake. This activity has been associated in vivo with increased extracellular dopamine levels in some brain regions of animals. In genetically engineered mice lacking the dopamine transporter (DAT), modafinil lacked wake-promoting activity, suggesting that this activity was DAT-dependent. However, the wake-promoting effects of modafinil, unlike those of amphetamine, were not antagonized by the dopamine receptor antagonist haloperidol in rats. In addition, alpha-methyl-p-tyrosine, a dopamine synthesis inhibitor, blocks the action of amphetamine, but does not block locomotor http://www.accessdat...s013s018lbl.pdf activity induced by modafinil. Share this post Link to post Share on other sites
Posted April 13, 2013 SPMM: Activates neurons containing orexins Share this post Link to post Share on other sites
