aums

what exactly is therapeutic window?

8 posts in this topic

A clear therapeutic window is noted for which of the following?

Select one:
Nortriptyline
Amitriptyline
       Carbamazepine
Fluoxetine
Clozapine

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also confused about this one.

 

Which of the following undergoes metabolism predominantly by first order kinetics?

Select one:
Phenytoin
Depot antipsychotics
Venlafaxine XL
Alcohol
Thioridazine

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phenytoin, alcohol, depot injections, XL drugs(extended release) - exhibit zero order kinetics

 

hence the answer is thioridazine

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2 hours ago, psychtrainee2015 said:

phenytoin, alcohol, depot injections, XL drugs(extended release) - exhibit zero order kinetics

 

hence the answer is thioridazine. 

 

I was actually confused about venlafaxine xl. So if it's just venlafaxine, we'll say it follows 1st order. Am I right?

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3 hours ago, psychtrainee2015 said:

Answer for clear therapeutic window---

"Nortriptyline"

 

as this has evidence based on a systemic review and meta analysis:

http://stevenbagley.net/blog/files/ntp.pdf

 

thanks

3 hours ago, psychtrainee2015 said:

phenytoin, alcohol, depot injections, XL drugs(extended release) - exhibit zero order kinetics

 

hence the answer is thioridazine

I was actually confused about venlafaxine xl. So if it's just venlafaxine, we'll say it follows 1st order. Am I right?

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2 hours ago, psychtrainee2015 said:

yes you are absolutely right.....if its just venlafaxine then 1st oder

great. thanks so much

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