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ISQs from Part 2 Spring 2003 (1 of 4)

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ISQs from Part II ; Spring 2003

1.      proteomes are collections of proteins in a cell.

2.      Transcriptosomes are collections of transcribed DNA.

3.      Heterozygous autosomal dominance can lead to a variable penetrance

4.      Biological rather than adopted parents of an adopted schizophrenic have more affective illness [depression]

5.      Behavioural problems is mostly genetic in adopted children

6.      Environmental effect is more on homozygous female twins than on homozygous male twins when adopted.

7.      First born sons are more prone to alcohol dependence.

8.      Protozoal infections in pregnancy lead to cognitive impairment

9.      Mumps in pregnancy leads to cognitive impairment

10.      CMV in pregnancy leads to cognitive impairment

11.      Recurrent UTI in pregnancy leads to cognitive impairment.

12.      Imperforate anus at birth suggests Down;s syndrome.

13.      Angelman;s syndrome is due to paternal deletion of chromosome 15.

14.      Angelman;s syndrome had hyperphagia and cognitive impairment.

15.      Uniparental disomy is more a cause of angelmann;s than Prader Willi syndrome.

16.      Most people with 47XYY do not have behavioural problems .

17.      Aggression is over represented in 47XYY.

18.      EEG has exaggerated spikes in Huntington's disease.

19.      Port wine stain is seen in tuberous sclerosis.

20.      People with Chronic Fatigue Syndrome have more emotional problems than Myotonic dystrophy.

21.      Children with CFS have more problems than chronic juvenile arthritis.

22.      People who accept a psychological cause for CFS do better.

23.      Hurler's syndrome can be treated by diet.

24.      Phenylketonuria can be treated with increasing tryptophan in the diet.

25.      Fragile X can be diagnosed by amniocentesis.

26.      Fragile X is seen not to have speech and language difficulties.

27.      Phenylketonuria is found 1 in 20,000

28.      Asperger's is seen only in males.

29.      Fragile X has CAG repeats.

30.      People with autism are unable to make direct eye to eye contact.

31.      There is a 5% chance of bipolar homozygous twins developing schizophrenia.

32.      Considering ventricular dilatation on CT, there is a qualitative difference between bipolar and schizophrenia.

33.      MR spectroscopy shows N-acetyl aspartate deficiency in schizophrenia.

34.      Leukoariosis is significant in a patient with dementia and gait disturbance.

35.      Leukoariosis in old age is seen in anxiety and depression.

36.      SPET I123 IBZ is used for 5HT2 receptors.

37.      SPET I123 ...[can't remember] is used for benzodiazepine receptors.

38.      Shrunken frontal lobes indicates Pick's than Alzheimer;s.

39.      Hypometabolism of prefrontal cortex is associated with schizophrenia.

40.      DHEA opposes the effects of cortisol

41.      T4 is raised in anorexia nervosa.

42.      GH blunting is seen in depression.

43.      Tryptophan induced prolactin suppression is seen in depression

44.      Peripheral CCK release reduces satiety.

45.      Heroin is more potent at m receptor than cocaine.

46.      ACTH is raised in depression.

47.      Dexamethasone non-suppression is seen in 90% of depressives.

48.      Dexamethasone non-suppression can be diagnostic of depression.

49.      Population pyramids are used for age/sex.

50.      Regression analysis for continuous data is done by least squares method.

51.      Least squares method is used for regression of categorical data.

52.      Correlation indicates agreement.

53.      Test +ve/_ve fits into binomial distribution from a random sample.

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1. A transcriptome is a collection of messenger RNA molecules derived from genes whose protein products are needed by the cell. It is generated by transcription of mRNA by DNA dependent RNA polymerase and will vary from cell type to cell type and potentially over the lifetime of the cell or in different environments that the cell encounters. ::) 8)

2. A proteome is a cell’s repertoire of proteins; it dictates the cell’s function. It is generated by translation, the process of converting the information in RNA molecules into proteins. 8)

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