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Guest santhana

ISQs in Neuropharmacology

7 posts in this topic

NEUROPHARMACOLOGY

1. In Seasonal Affective Disorder, melatonin secretion at night increases in the winter

2. DHEA has an effect opposite to the effects of cortisol

3. The ratio of cortisol to DHEA is increased in adolescents with depression

4. Glutamate is a NMDA antagonist

5. Acamprosate is a NMDA antagonist

6. 5-HT3 receptors are linked to Na-Ion channels

7. Heteroreceptors cause decrease neurotransmitter release through presynaptic mechanisms

8. Heteroreceptors cause decrease neurotransmitter release through presynaptic mechanisms

9. Reboxetine causes 5-HT2 blockade

10. With NA-reuptake inhibitors, presynaptic alpha-2 receptors are likely to be more sensitive to blockade

11. There is usually a greater fall of cortisol following dexamethasone in depression than in normal volunteers

12. 80 % of depressed children have a positive dexamthesone suppression test

13. Bupronorphine is a GABA antagonist

14. Atypical neuroleptics have a longer D2 receptor occupancy than typical neuroleptics

15. D5 receptors belong to the D1 family of receptors

16. The dexamethasone suppression test is a reliable test for depression in the elderly

17. PTSD is associated with an exaggerated fall in cortisol following dexamethasone than in

18.SPECT I123 IBZ is used for 5HT2 receptors.

19.SPECT I123 ...[can't remember] is used for benzodiazepine receptors.

20.Tryptophan induced prolactin suppression is seen in depression

21.Peripheral CCK release reduces satiety.

22.Heroin is more potent at m receptor than cocaine.

23.ACTH is raised in depression.

24.Dexamethasone non-suppression is seen in 90% of depressives.

25.Dexamethasone non-suppression can be diagnostic of depression.

26. Insulin release by the pancreas reduces tyrosine/tryptophan

27.Phencyclidine affects NMDA.

28.Melatonin hypersecretion is reliably proved in SAD.

29.If a person has depression in summer, you cannot diagnose SAD.

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11.failed supperssion of cortisol by dexamthasone in depression, but also schizophrenia (?and dementia) therefore not specific

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29 false could diagnose worsening in winter due to additional SAD

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6. true

5ht1a autorec linked to cAMP and adenylate cyclase

5ht1b ONLY in animals '

5ht2a linked inositol and ip3

5ht 2c/1c inositol and ip3

5ht1d assoc migraine

5ht 1e/f unknown function

5ht3 post syn na / k channel anatg by ondansetron ? novel antipsychotic

5ht 6 / 7 adenylaye cyclase

(taken from companion)

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