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      New question bank for paper B   05/11/18

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lenakathiravan

any psycopharmacologists here?

2 posts in this topic

'Pharmacokinetic differences between SSRIs are more important. Fluoxetine differs in having a much longer elimination half-life (1–3 days, seproxetine (norfluoxetine – its active metabolite) 7–15 days) than that of its competitors, which range from about 0.5 to 1.5 days. This means that it takes longer to reach steady state (and possibly effective) plasma concentrations and that a substantially longer washout period is required if drugs that interact with fluoxetine are to be prescribed.'

From:

Advances in Psychiatric Treatment (2001) 7: 170-180

© 2001 The Royal College of Psychiatrists

Guidelines for choice of selective serotonin reuptake inhibitor in depressive illness

Ian M. Anderson and J. Guy Edwards

I think this means that it's the same as norfluoxetine, i.e. the active metabolite of fluoxetine. I pasted it in because it's not 100% clear if that's what it means.

It's not a bad paper anyway, worth looking at.

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