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Guest khuram

Any suggestions(organic)

5 posts in this topic

1.10% of alzheimers is due to variations in the preselinin gene..

2.Wilsons disease is a known cause of delerium.

3.Vascular dementia is more common than Alzheimer's in 65 - 75 yr olds.

4.Auditory hallucinations present in Alcohol withdrawal.

5.Elderly patient with 1st episode of depression more likely to have large ventricles than someone of the same age with several previous episodes.

6.Leukoaraiosis leads to gait disturbance in dementia.

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2.Wilsons disease is a known cause of delerium.

True. Anything can cause delirium! Disease has hepatological and neurological sequelae, so these can cause delirium.

3.Vascular dementia is more common than Alzheimer's in 65 - 75 yr olds.

Alzheimer's is the commonest dementia and increases as age increases. Probably TRUE, though unsure

4.Auditory hallucinations present in Alcohol withdrawal.

Mainly visual and tactile hallucinations. Auditory more prominent in alcoholic hallucinosis. Auditory can present, but not typical, so not sure. True?

5.Elderly patient with 1st episode of depression more likely to have large ventricles than someone of the same age with several previous episodes.

True. Old age depression more asscociated with brain pathology and cognitive impairment

6.Leukoaraiosis leads to gait disturbance in dementia.

True. Vascular type

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1.10% of alzheimers is due to variations in the preselinin gene

i think FALSE.

there are 2 presenelin genes implicated in the aetiology of alzheimers.

both are less than 5%.

ref:http://www.mtsinai.on.ca/FamMedGen/Disorders/alzheimers.htm#table1

Early Onset- chromosome 14: Presenelin I (PS-1) <5%.

Chromosome 1: Presenelin II (PS-II) <1%

Chromosome 21: Amyloid Precursor protein 1-3%

Late Onset Chromosome 19: Apolipoprotein E risk factor only 40-50%

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Bit stuck on these two:

Q

1. The difference between prion protein and scrapie protein is a disulphide bond.

2. A similarity between impaired cognition in old age and Alzheimer's is impaired visuo-spatial scratch pad.

A

1. in Manc course it says that diff btwn prion protein and nvCJD is a disulphide bond. Is this the same for sheep? Who cares?!

2. Not sure.

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2. A similarity between impaired cognition in old age and Alzheimer's is impaired visuo-spatial scratch pad.

True

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