• Announcements

    • Gurpal

      New question bank for paper B   05/11/18

      Please see the link below for a new question bank: http://www.superegocafe.com/online-courses/mrcpsych-paper-b-multiple-choice-question-bank/  
Sign in to follow this  
Followers 0
dharma

drugs

19 posts in this topic

1. amphetamine causes physical dependance

2. amphetamine abuse causes macrocytosis

3. lsd intoxication is associated with formication

4. lsd is associated wtih withdrawl delirium

5. MDMA causes physical dependance

6. lsd causes physical dependance

7. ecstasy is associated with a withdrawl state

... and no I can't seem to get any sleep today!! :'(

Share this post


Link to post
Share on other sites

... and no I can't seem to get any sleep today!!

were u thinking about some thing exciting! :-?

1. amphetamine causes physical dependance

True

strong psychological and pharmacological factors motivate continued use and the progression to dependence

Kaplan & Sadock's Comprehensive Textbook of Psychiatry

amphetamine abuse causes macrocytosis

False

alcohol is the culprit.

Share this post


Link to post
Share on other sites

3. lsd intoxication is associated with formication

false

skin (formication), are common in alcohol withdrawal syndromes and in cocaine intoxication

Physical dependence on lysergide does not seem to occur.

4. lsd is associated wtih withdrawl delirium

I wonder if thinking about (a 'bad trip')makes this answer true?.

Share this post


Link to post
Share on other sites

MDMA causes physical dependance

false

there is no DSM-IV-TR diagnosis for hallucinogen withdrawal. Hallucinogen use, even for individuals who meet the criteria for a diagnosis of dependence, is rarely more than one dose a week and usually much less frequent. Evidence of craving for hallucinogens is equivocal, with the possible exception of MDMA.

kaplan

Share this post


Link to post
Share on other sites

a few more drugs questions

8. butane abuse can cuase visual hallucinations

9. visual halluciantions are a recognised feature of cannabis use

10. cocaine use can cause a psychosis lasting up to 4 weeks

::)

Share this post


Link to post
Share on other sites

8. butane abuse can cuase visual hallucinations

TRUE

9. visual halluciantions are a recognised feature of cannabis use

FALSE

10. cocaine use can cause a psychosis lasting up to 4 weeks

True

Share this post


Link to post
Share on other sites

4 more:

1.Benzodiazepines may increase beta waves on the EEG

2.Alpha-2 adrenoceptors when stimulated, reduce the blood pressure in man.

3.Alpha-2 adrenoceptors when challenged with clonidine are associated with blunted growth hormone responses in patients with panic disorder.

4.Alpha-2 adrenoceptors when stimulated suppress the symptoms of acute opiate withdrawal.

Share this post


Link to post
Share on other sites

1.Benzodiazepines may increase beta waves on the EEG

TRUE (Benzos and barbiturates increase Beta waves - to remember: BBB)

2.Alpha-2 adrenoceptors when stimulated, reduce the blood pressure in man.

TRUE (as in both lofexidine and clonidine)

;)Happy revision ... (not :P)

Share this post


Link to post
Share on other sites

1.Benzodiazepines may increase beta waves on the EEG

TRUE

revision notes in psych, puri and hall

Share this post


Link to post
Share on other sites

3.Alpha-2 adrenoceptors when challenged with clonidine are associated with blunted growth hormone responses in patients with panic disorder.

TRUE.

Adrenoceptor sensitivity, investigated by the clonidine test, is reduced in panic disorder.

REF:Psychoneuroendocrinology. 1995;20(1):1-9.

Share this post


Link to post
Share on other sites

4.Alpha-2 adrenoceptors when stimulated suppress the symptoms of acute opiate withdrawal.

TRUE.

Chronic administration of prescribed or illegal opioids leads to biological adaptations that influence the function of 2 adrenoceptors, which can be significantly modified by the ligands of these receptors: thus, cross-tolerance has been described between opioid and 2 agonists, and these latter drugs effectively block the manifestations of opioid withdrawal in animals and humans. Conversely, 2- adrenoceptor antagonists prevent the development of tolerance or dependence when coadministered with chronic opioids and increase withdrawal signs when acutely injected to abstinent subjects.

ref: Current Neuropharmacology, Volume 2, Number 4, October 2004, pp. 343-352(10)

Share this post


Link to post
Share on other sites

RE: ALPHA 2 RECEPTORS AND GROWTH HORMONE RESPONSE

Several studies have shown that panic disorder is associated with an increased sensitivity to yohimbine and a blunted growth hormone response to clonidine, which are alpha-2 adrenoceptor antagonist and agonist, respectively.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14656453&query_hl=5&itool=pubmed_docsum

Share this post


Link to post
Share on other sites

4.Alpha-2 adrenoceptors when stimulated suppress the symptoms of acute opiate withdrawal.

True

Share this post


Link to post
Share on other sites
... and no I can't seem to get any sleep today!!

were u thinking about some thing exciting! :-?

1. amphetamine causes physical dependance

True

strong psychological and pharmacological factors motivate continued use and the progression to dependence

Kaplan & Sadock's Comprehensive Textbook of Psychiatry

amphetamine abuse causes macrocytosis

False

alcohol is the culprit.

Are amphetamine and cocaine addictive?

Pobably not. I have added the following exerpt from the Oxford Book of Psychiatry.

It is commonly observed that amphetamine and cocaine are non-addictive, or cause psychological but not physical dependence. Such observations rest on a distinction in which the condition of addiction, or physical dependence, requires visible bodily withdrawal symptoms, but critics claim that this is of limited meaning now that there is an understanding of the neurobiological basis of drug withdrawal states. The current classification systems do retain some distinctions between physical and psychological dependence, and the issue is largely one of definition and semantics. The credibility of the label ‘non-addictive’ is certainly tested when individuals are encountered who have injected amphetamine 10 or more times every day for many years, or who spend vast amounts of money using crack in a highly compulsive manner.

Share this post


Link to post
Share on other sites
MDMA causes physical dependance

false

there is no DSM-IV-TR diagnosis for hallucinogen withdrawal. Hallucinogen use, even for individuals who meet the criteria for a diagnosis of dependence, is rarely more than one dose a week and usually much less frequent. Evidence of craving for hallucinogens is equivocal, with the possible exception of MDMA.

kaplan

I feel the answer to this one is True, I have attached a referance from the Oxford Text Book of Psychiatry

DSM-IV lists psychiatric effects of phencyclidine including intoxication, delirium, phencyclidine-induced psychotic, mood, and anxiety disorders, and phencyclidine abuse and dependence. A criterion for diagnosis is the emergence of the disorder within a month of drug use. While these disorders have been reported in anecdotes, a substantial clinical characterization exists for phencyclidine delirium and psychosis.

Share this post


Link to post
Share on other sites

1. amphetamine causes physical dependance t may cause

2. amphetamine abuse causes macrocytosis f

3. lsd intoxication is associated with formication f cocaine

4. lsd is associated wtih withdrawl delirium f

5. MDMA causes physical dependance f

6. lsd causes physical dependance f

7. ecstasy is associated with a withdrawl state t

Share this post


Link to post
Share on other sites

I note the discussion above about amphetamine causing physical dependence and the subtleties of distinguishing between 'physical' and 'psychological' addiction. I would note however that a physiological withdrawal state (as opposed to psychological 'coming down' ) for amphetamine doesn't really exist (unlike, for example, heroin, alcohol, benzos and barbs) and therefore think that the answer is False.

Share this post


Link to post
Share on other sites

7. ecstasy is associated with a withdrawl state

FALSE.

Ecstasy does not really have a withdrawal syndrome associated with it. There is a crash, like with other stimulants, where you may sleep for several days if you' ve been using large amounts. But there is no ' withdrawal 'so to speak. However, there are severe side effects like fatigue, depressed feelings, panic or anxiety. This is the direct result of damage to your brain. While these symptoms may improve with time, if you continue to use these drugs, you will constantly stay in this state.

Share this post


Link to post
Share on other sites

Are amphetamine and cocaine addictive?

Pobably not. I have added the following exerpt from the Oxford Book of Psychiatry.

It is commonly observed that amphetamine and cocaine are non-addictive, or cause psychological but not physical dependence. Such observations rest on a distinction in which the condition of addiction, or physical dependence, requires visible bodily withdrawal symptoms, but critics claim that this is of limited meaning now that there is an understanding of the neurobiological basis of drug withdrawal states. The current classification systems do retain some distinctions between physical and psychological dependence, and the issue is largely one of definition and semantics. The credibility of the label ‘non-addictive’ is certainly tested when individuals are encountered who have injected amphetamine 10 or more times every day for many years, or who spend vast amounts of money using crack in a highly compulsive manner.

I am so sorry for the confusion but found this in Oxford too.

Strong opiates and cocaine are the most addictive, being in the same class as nicotine. The benzodiazepines, ecstasy, and psychedelics are the least addictive, and are significantly less addictive than alcohol.

New Oxford Textbook of Psychiatry

and on this basis:

Ecstasy causes more physical dependence than cocaine  

False

I however agree that amphetamine causes physical dependance.False

Share this post


Link to post
Share on other sites
Sign in to follow this  
Followers 0