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PSYCHOPHARMACOLOGY ISQs

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Psychopharmacology Qs

1. Phenelzine has significant interaction with salbutamol

2. Action on 5HT3 receptors may have an antidepressant effect

3. Memantine is a NMDA receptor antagonist

4. St John’s wart reduces the anticoagulant effects of Warfarin

5. After reaching a steady state, plasma drug concentration can fluctuate

6. &nbsp:lol:onepezil has a drug half life of 70 hrs which makes it ideal for once daily dosing

7. Most of the psychotropic drugs have metabolites which are ionised

8. Haloperidol is lipophilic

9. Propanolol is lipophilic

10. Amitriptyline can cause significant weight gain

11. Rivastigmine is useful for aggression in Lewy body dementia

12. Gabapentin has a prophylactic effect in the treatment of Bipolar disorder

13. NMS is seen more in females than males

14. NMS is seen more in old age

15. NMS is seen with concurrent Lithium carbonate use with neuroleptics

16. Olanzapine can be safely used in Closed angle glaucoma

17. Clozapine causes Hyperprolactinemia

18. Tricyclics increase the concentration of Chlorpromazine

19. SSRIs inhibit Cytochrome P540 enzyme

20. Tricyclics can cause sinus bradycardia

21. Carbamazepine reduces the effect of Calcium channel blockers

22. Olanzapine is a substituted benzamide

23. Explaining side effects of medication reduces compliance

24. Lithium increases serum Haloperidol levels

25. Having active metabolites of a drug helps in crossing Blood brain barrier (BBB)

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26. Lithium is the smallest alkaline cation

27. Haloperidol is antiemetic

28. &nbsp:lol:opamine is lipophilic

29. Signs of Lithium toxicity in newborn are Hypotonia and Cyanosis

30. St John’s wart reduces the efficacy of Oral contraceptives

31. St John’s wart reduces the activity of Warfarin

32. &nbsp:lol:iazepam crosses the placenta

33. Clearance of a drug is proportional to plasma concentration if enzymes are not saturated

34. Amisulpride is excreted unchanged in the kidney

35. As long as Lithium level in mother is less than 0.8, breastfeeding is safe for the baby

36. Tricyclics increase the QTc on ECG

37. Tranylcypromine causes sedation in the majority of patients who take it

38. Imipramine causes dry mouth due to blocking of peripheral muscarinic receptors

39. Lithium is more effective in patients with a family history of good response to it

40. Amiloride is used to treat Lithium induced polyuria

41. Lithium is lipophilic

42. Highly protein bound drugs are likely to be excreted in breast milk

43. Olanzapine is contraindicated in Closed angle glaucoma

44. Clozapine is contraindicated in Parkinson’s disease

45. Polypharmacy is a common cause of Delirium in old age

46. Rate of decline of a drug is determined by the concentration of the drug as long as the metabolic processes involved are not saturated

47. Hypersalivation,sedation and galactorrhoea are side effects of Clozapine

48. Risperidone is a potent 5HT2 antagonist

49. Buspirone is a GABAb antagonist

50. There are clinically significant antidepressant effects of 5HT3 antagonism

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51. Salbutamol may lead to hypertensive crises if given with MAOI

52. Antidepressants mediate their antidepressant action through 5HT3 receptors

53. &nbsp:lol:ry mouth by tricyclics is mediated through an adrenergic blockage

54. Flupenthixol only starts acting after 36 hrs

55. Recent myocardial infarction is a contraindication for Carbamazepine therapy

56. &nbsp:lol:opamine is a precursor of Adrenaline

57. &nbsp:lol:opamine is metabolised by MAO

58. Clozapine has high affinity to D1 receptors compared to other antipsychotics

59. &nbsp:lol:ipyridamoles are antipsychotics

60. &nbsp:lol:ibenzodiazepines are antipsychotics

61. Tardive dyskinesia is more common in elderly men than elderly women treated with antipsychotics

62. There is an increased risk of Tardive dyskinesia in people treated with antipsychotics with a history of Bipolar affective disorder

63. Tardive dyskinesia can be worsened by treatment with antimuscarinic agents

64. Tricyclic antidepressants have a direct toxic effect on the cardiac myocardia

65. Myoclonus is a sign of Serotonin syndrome

66. Mirtazepine inhibits Serotonin reuptake

67. Reboxetine inhibits Serotonin reuptake

68. Valproate has been associated with neural tube defects when prescribed in pregnancy

69. Carbamazepine acts by blocking Sodium channels

70. A person can safely eat cheese two weeks after stopping Phenelzine

71. Moclobemide does not interact with Tyramine

72. Phenelzine can be used in the treatment of Anxiety disorders

73. Tranylcypromine caused Hypotension and sedation

74. Benzodiazepines increase EEG fast wave activity

75. Benzodiazepines can cause anterograde amnesia at therapeutic doses

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76. Buspirone causes tolerance after prolonged use

77. Buspirone acts on 5HT1A reeptors

78. Ionised drugs cross the BBB easily

79. Clozapine has very high affinity for D2 receptors

80. Clozapine has very high affinity for D4 receptors

81. Clozapine is more effective at D4 receptor than standard antipsychotics

82. Stopping antipsychotics can precipitate Tardive dyskinesia

83. Morphine should not be given with TCAs

84. TCAs inhibit MAO

85. Trazodone has antimuscarinic properties

86. Lithium causes Alopecia

87. St John’s wort increases the efficacy of Fluoxetine

88. Benzodiazepines increase fast wave activity in the frontal lobe

89. Benzodiazepines suppress REM sleep

90. Benzodiazepines have specific binding sites on receptors

91. Phenytoin inhibits GABA transaminase

92. Lamotrigine inhibits GABA transaminase

93. A high lipid partrition coefficient makes it easier for drugs to pass through cellular membrane

94. &nbsp:lol:rugs with high lipid partrition coefficient pass the BBB

95. Fluoxetine has significant anti-muscarinic side effects at therapeutic doses

96. Reboxetine is a reversible inhibitor of MAO-A

97. Lithium given in first trimester of pregnancy leads to cardiac abnormalities

98. Increased weight gain due to Lithium is seen more often in women than men

99. Valproate causes significant weight gain at therapeutic doses

100 Moclobemide is a RIMA

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101 Selegeline is a selective MAO-B inhibitor

102 Lamotrigine acts via GABA transaminase

103 Pentazocine causes hallucinations

104 Clozapine is a 5HT2 agonist

105 Clozapine does not have significant anti-muscarinic effects at therapeutic doses

106 In studies, Chlorpromazine levels have been reduced by anti-muscarinics

107 Antipsychotics cause Intention tremor

108 Stopping antipsychotics can precipitate EPSE

109 EPSEs can occur in fetus folloqing treatment of its mother during pregnancy with antipsychotics

110 Carbamazepine and Warfarin have a potentially dangerous interaction at therapeutic doses

111 Benzodiazepine action is potentiated by Cimetidine

112 Benzodiazepines induce hepatic enzymes

113 The difference in action between drugs given by parenteral and oral routes can be explained due to the First pass effect

114 Nasal inhalers bypass the BBB

115 Low binding to plasma proteins helps psychotropics pass cellular membranes

116 SSRIs increase REM sleep

117 Reboxetine is an SSRI

118 Lithium causes Hypothyroidism more commonly in women than men

119 MAO is found in the outer mitochondrial membrane

120 Phenelzine is contraindicated with Pethidine

121 Chlorpromazine can increase levels of TCAs

122 The oral dose of Chlorpromazine causes varying plasma levels

123 Haloperidol decreases central action of amphetamines

124 Fluphenazine inhibits reuptake of Serotonin

125 Sulpiride is water soluble

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126 Pancytopenia is a clinically significant side effect of Clozapine

127 Phenobarbitone causes paradoxical excitement

128 Pharmacokinetics in elderly people is affected by decreased body fluid/water

129 In pharmacokinetic terms, First pass metabolism has occurred if drug has failed to reach the carotid arteries

130 Highly ionised drugs pass the BBB

131 Clomipramine acts on postsynaptic 5HT receptors

132 Lofepramine levels are increased by Chlorpromazine

133 MAOIs can react with Cocaine

134 MAOIs can react with Fenfluramine

135 Fermented soya beans should be avoided with MAOIs

136 Lithium may cause hypoparathyroidism

137 Carbamazepine and Lithium combined in their therapeutic doses could lead to neurotoxicity

138 Mortality in ECT is the same as during GA in minor surgery

139 Psychotropics are secreted via bile duct in the Enterohepatic circulation

140 &nbsp:lol:iazepam causes excitement in therapeutic doses

141 Anhedonia can be induced by Barbiturates

142 Excessive weight loss is caused by Fluoxetine

143 SSRIs can be given with MAOIs

144 Carbamazepine interferes significantly with oral contraceptive pills

145 Haloperidol acts on D2 receptors

146 Haloperidol increases Prolactin levels

147 Olanzapine can cause Hyperglycemia

148 Amphetamines increase the functional level of Dopamine in the brain

149 Patient permission is required for notification of a Heroin abuser

150 HIV testing is mandatory in all Heroin users

151 Propanolol crosses the BBB

152 General anesthetics alter the BBB permeability

153 Intranasal sprays avoid the BBB

154 BBB is abolished by inhaling anesthetic gases

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and now the Psychpharma ISQs from the Spring 2006 paper

155 Carbamazepine is a Ca channel blocker

156  Paroxetine increases Aripriprazole levels

     157   Diazepam is lipophilic

     158  Valproate causes weight gain

     159  Pancytopenia is caused by Clozapine

     160  Risperidone is a dibenzodiazepine

     161  MAO blocks the uptake of Serotonin and Dopamine

     162  Tyrosine hydroxylase is involved in the synthesis of Dopamine

     163  Clomipramine has both serotonergic and noradrenergic properties

     164  Sexual side effects of SSRIs are due to 5HT2

     165   Benzodiazepines act on GABA-A receptor

     166   Valproate decreases serum Lamotrigine levels

     167   Elderly patients absorb the same amount of drug but slowly

168  In elderly patients the proportion of body fat is more

169   Explaining side effects of drugs decreases compliance

170   SSRIs can cause hyponatremia at therapeutic doses

171   Less protein binding increases the permeability of the Blood brain barrier

172   Procyclidine causes ataxia at therapeutic doses

173   Phenelzine has significant effect with Salbutamol

174   Fluphenazine inhibits reuptake of 5HT

175   Most drugs which act on 5HT2 receptors cause sedation

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Psychpharma ISQs from the Spring 2006 paper

155 Carbamazepine is a Ca channel blocker f

156  Paroxetine increases Aripriprazole levels t

     157   Diazepam is lipophilic t

     158  Valproate causes weight gain t

     159  Pancytopenia is caused by Clozapine f

     160  Risperidone is a dibenzodiazepine f

     161  MAO blocks the uptake of Serotonin and Dopamine t

     162  Tyrosine hydroxylase is involved in the synthesis of Dopamine t

     163  Clomipramine has both serotonergic and noradrenergic properties t

     164  Sexual side effects of SSRIs are due to 5HT2 true

     165   Benzodiazepines act on GABA-A receptor f

     166   Valproate decreases serum Lamotrigine levels False, ( Increases)

     167   Elderly patients absorb the same amount of drug but slowly t

168  In elderly patients the proportion of body fat is more t

169   Explaining side effects of drugs decreases compliance f

170   SSRIs can cause hyponatremia at therapeutic doses t

171   Less protein binding increases the permeability of the Blood brain barrier f

172   Procyclidine causes ataxia at therapeutic doses t

173   Phenelzine has significant effect with Salbutamol f

174   Fluphenazine inhibits reuptake of 5HT f

175   Most drugs which act on 5HT2 receptors cause sedation f

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Thank you for collecting these questions  :)

131  Clomipramine acts on postsynaptic 5HT receptors

132  Lofepramine levels are increased by Chlorpromazine

I am stuck on these 2

Any help?

Sandi

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131  Clomipramine acts on postsynaptic 5HT receptors

FALSE

132  Lofepramine levels are increased by Chlorpromazine

TRUE

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152 General anesthetics alter the BBB permeability false

153 Intranasal sprays avoid the BBB false

154 BBB is abolished by inhaling anesthetic gases false

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Psychopharmacology Qs

20. Tricyclics can cause sinus bradycardia false

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Intranasal sprays avoid the BBB  -------------T

 

False

I couldn't find any reference for it being true.

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131  Clomipramine acts on postsynaptic 5HT receptors

FALSE

132  Lofepramine levels are increased by Chlorpromazine

False

BNF clearly says chlorpromazine may increase TCA levels But as TCA don,t do any thing to ezyme system so these do not effect levels

Cheers Kamran(Inzi)

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Intranasal sprays avoid the BBB  -------------T

Babrak Nothing can avoid BBB

Cheers

   

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131  Clomipramine acts on postsynaptic 5HT receptors

FALSE

132  Lofepramine levels are increased by Chlorpromazine

False

BNF clearly says chlorpromazine may increase TCA levels But as TCA don,t do any thing to ezyme system so these do not effect levels

Cheers Kamran(Inzi)

Lofepramine levels are increased by Chlorpromazine   true

Cholrpromazine levels are increased by lofepramine true

Drug interactions in psychiatry ---Lippincott

Kaplan Synopsis says both TCAs and chlorpromazine raise levels of each other. Chlorpromazine inhibits cyt. p450 while   TCAs raise chlorpromazine levels by some unknown mechanism.

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175 Most drugs which act on 5HT2 receptors cause sedation True(birmingham course)

Psychpharma ISQs from the Spring 2006 paper

155 Carbamazepine is a Ca channel blocker f

156 Paroxetine increases Aripriprazole levels t

157 Diazepam is lipophilic t

158 Valproate causes weight gain t

159 Pancytopenia is caused by Clozapine f

160 Risperidone is a dibenzodiazepine f

161 MAO blocks the uptake of Serotonin and Dopamine t

162 Tyrosine hydroxylase is involved in the synthesis of Dopamine t

163 Clomipramine has both serotonergic and noradrenergic properties t

164 Sexual side effects of SSRIs are due to 5HT2 true

165 Benzodiazepines act on GABA-A receptor f

166 Valproate decreases serum Lamotrigine levels False, ( Increases)

167 Elderly patients absorb the same amount of drug but slowly t

168 In elderly patients the proportion of body fat is more t

169 Explaining side effects of drugs decreases compliance f

170 SSRIs can cause hyponatremia at therapeutic doses t

171 Less protein binding increases the permeability of the Blood brain barrier f

172 Procyclidine causes ataxia at therapeutic doses t

173 Phenelzine has significant effect with Salbutamol f

174 Fluphenazine inhibits reuptake of 5HT f

175 Most drugs which act on 5HT2 receptors cause sedation f

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161 MAO blocks the uptake of Serotonin and Dopamine t

MAO degrades NA, 5HT and Dopamine. Its not associated with blocking the uptake.

I would answer False to this question

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161  MAO blocks the uptake of Serotonin and Dopamine  t

MAO degrades NA, 5HT and Dopamine. Its not associated with blocking the uptake.

I would answer False to this question

Thanks Prince!!

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131  Clomipramine acts on postsynaptic 5HT receptors

FALSE ( presynaptic)

132  Lofepramine levels are increased by Chlorpromazine

( chlorpromazine inhibit the enzy systen and hence increase the levels)

TRUE

Tha

Ather

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Pancytopenia is a clinically significant side effect of Clozapine F

127 Phenobarbitone causes paradoxical excitement T

128 Pharmacokinetics in elderly people is affected by decreased body fluid/water T

129 In pharmacokinetic terms, First pass metabolism has occurred if drug has failed to reach the carotid arteries T

130 Highly ionised drugs pass the BBB F

131 Clomipramine acts on postsynaptic 5HT receptors F

132 Lofepramine levels are increased by Chlorpromazine T

133 MAOIs can react with Cocaine T

134 MAOIs can react with Fenfluramine T

135 Fermented soya beans should be avoided with MAOIs T

136 Lithium may cause hypoparathyroidism T

137 Carbamazepine and Lithium combined in their therapeutic doses could lead to neurotoxicity T

138 Mortality in ECT is the same as during GA in minor surgery T

139 Psychotropics are secreted via bile duct in the Enterohepatic circulation T

140 &nbsp:lol:iazepam causes excitement in therapeutic doses T

141 Anhedonia can be induced by Barbiturates T

142 Excessive weight loss is caused by Fluoxetine ?EXCESSIVE, they cause anorexia with weight loss but increased apetite with weight gain is also reported with citalopram..Prince

143 SSRIs can be given with MAOIs F

144 Carbamazepine interferes significantly with oral contraceptive pills T

145 Haloperidol acts on D2 receptors T

146 Haloperidol increases Prolactin levels T

147 Olanzapine can cause Hyperglycemia T

148 Amphetamines increase the functional level of Dopamine in the brain T

149 Patient permission is required for notification of a Heroin abuser T

150 HIV testing is mandatory in all Heroin users F

151 Propanolol crosses the BBB T

152 General anesthetics alter the BBB permeability F

153 Intranasal sprays avoid the BBB F

154 BBB is abolished by inhaling anesthetic gases F... Prince

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Pancytopenia is a clinically significant side effect of Clozapine  F

127  Phenobarbitone causes paradoxical excitement  T

128  Pharmacokinetics in elderly people is affected by decreased body fluid/water T

129  In pharmacokinetic terms, First pass metabolism has occurred if drug has failed to reach the carotid arteries  T

130 Highly ionised drugs pass the BBB  F

131  Clomipramine acts on postsynaptic 5HT receptors  F

132  Lofepramine levels are increased by Chlorpromazine  T

133  MAOIs can react with Cocaine  T

134  MAOIs can react with Fenfluramine T

135  Fermented soya beans should be avoided with MAOIs T

136  Lithium may cause hypoparathyroidism  T

137  Carbamazepine and Lithium combined in their therapeutic doses could lead to neurotoxicity T

138  Mortality in ECT is the same as during GA in minor surgery T

139  Psychotropics are secreted via bile duct in the Enterohepatic circulation T

140  Diazepam causes excitement in therapeutic doses  T

141  Anhedonia can be induced by Barbiturates  T

142 Excessive weight loss is caused by Fluoxetine ?EXCESSIVE, they cause anorexia with weight loss but increased apetite with weight gain is also reported with citalopram..Prince

143 SSRIs can be given with MAOIs F

144  Carbamazepine interferes significantly with oral contraceptive pills  T

145  Haloperidol acts on D2 receptors  T

146  Haloperidol increases Prolactin levels T

147  Olanzapine can cause Hyperglycemia  T

148  Amphetamines increase the functional level of Dopamine in the brain T

149  Patient permission is required for notification of a Heroin abuser T

150  HIV testing is mandatory in all Heroin users F

151  Propanolol crosses the BBB  T

152  General anesthetics alter the BBB permeability  F

153  Intranasal sprays avoid the BBB  F

154  BBB is abolished by inhaling anesthetic gases F... Prince

Sir any reference or ideas to support your answer

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Well your point is quite valid and I really appreciate this, but at this short time it is difficult to provide ref. for each and every question. If you have doubts in any answer please let us know and I shall try to find the reference. All the best for your exam. ;)

Inzi

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Well your point is quite valid and I really appreciate this, but at this short time it is difficult to provide ref. for each and every question. If you have doubts in any answer please let us know and I shall try to find the reference. All the best for your exam.  ;)

Inzi

yes thats true.

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