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Part II ISQ Club - Organic

46 posts in this topic

30 Part II ISQs on two topics will be posted twice a week. You are encouraged to post a reply in the thread, stating whether you think an ISQ is true or false and why (eg. a short explanation, with reference to the textbook you used). Please only deal with one ISQ in each post and include the question as the first line of your post. All ISQs are taken from previous posts by Forum members.

In a few days this ISQ Club thread will be moved to the Question Bank board. If you submit an answer, your status will be changed to 'Question Bank member' and you will be able to see the Question Bank board. Please allow up to 48 hours for this change to happen.

NOTE: NEXT ISQ CLUB POST WILL BE ON 16 FEBRUARY 2004.

1. Angelman's syndrome has a paternal cause

2. The brain in CJD shows spongiform changes without plaque formation

3. Most patients with CJD have abnormalities in CT scan

4. Early CJD is associated with definite EEG changes

5. Hachinski score is used to differentiate between Alzheimer's disease and Vascular dementia

6. Vascular dementia is associated with gait disturbance

7. Difficulties with spatial recognition are more likely from lesions with right-sided hemiplegia than left-sided

8. Phrase length is short in Broca's aphasia

9. Paraventricular 5HT (or histamine) nuclei are responsible for satiety

10. Acute intermittent porphyria can lead to hallucinations

11. Lewy bodies are present in 40% of dementias

12. Tau proteins interfere with microtubule formation

13. Nicotinic receptors are ion-gated

14. Proteomes are collections of proteins in a cell

15. White matter hyperintensities are most commonly periventricular

16. Decreased activity in the prefrontal cortex on PET scan is seen in obsessive compulsive disorder

17. Prominent cortical atrophy is seen in Wilson's disease

18. Leukoariosis is associated with cognitive decline

19. After a five year follow-up in penetrating head injury to the right cerebral cortex, there is strong evidence that apathy is a significant association

20. Imaging studies have shown increased blood flow to prefrontal cortex in post-traumatic stress disorder

21. Somnambulism is most likely to occur in Stage III and IV sleep

22. Metabolic disorders often cause increased alpha waves on the EEG

23. 80% of depressed children have a positive dexamthesone suppression test

24. In severe closed head injury CSF rhinorrhea occurs in more than 10%

25. A penetrating right sided head injury is likely to produce prosopagnosia

26. Children of people with schizophrenia are more likely to have mental disorder than children of people with personality disorder

27. Introversion is thought to be due to excessive sympathetic lability

28. Narcolepsy is associated with sudden onset REM sleep

29. SPET I123 IBZ is used to detect 5HT2 receptors

30. Up to 5 cells/mm is normal in CSF

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question 1

angleman syndrome has a paternal cause

False

angelman is due to deletion at 15q11-13 on maternal derived chromosome, Prader-Willi in contrast occurs due to deletion of paternal orgin.

companion to psychiatric studies p224

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question 2 - the brain in CJD shows spongiform changes without plaque formation

False

CJD is assoc with '' insoluable protien accumulation causing cell death and other pathological changes including spongiform changes , astrocyte proliferation and ON OCCASION amyloid plaque deposition''

vCJD - ''all at autopsy had spongiform changes and plaque formation''

Companion to psychiatric studies p306

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1 ) false The syndrome is characterized by severe mental retardation, jerky limb movements associated with abnormal gait, and inappropriate bouts of laughter, features which give the syndrome its name. This is a rare condition which affects between 1 in 20 000 and 1 in 30 000 people. In around 60 to 75 per cent of cases a deletion in the long arm of chromosome 15 (q11q13) could be detected. In the case of Angelman syndrome it is derived from the maternal source :o

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Q3- Most patients with CJD have abnormalities on CT

False

'structural neuroimaging may reveal cerebral atrophy' while in vCJD ' neuroimaging was usually normal or revealed non specific changes'

core psychiatry p386-7

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Q4- early CJD is associated with definite EEG changes

False

'the EEG of up to 90% shows a reduced backround rhythm with characteristic triphasic sharp wave complexes at 1-2 HZ, these may not be present initally and repeat recordings are necessary'

p386 core psychiatry

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Q5- Hachinski score is used to differentiate between AD and Vascular dementia

False??

certainly companion to psychiatric studies( p299) suggests it CAN be used , though its of little use and is of dubious value when age of onset is greater- and is n't widely used.

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Q6- vas dementia is assoc with gait disturbance

False

normal pressure hydrocephalus is more associated with gait problems , features of vas d is on p298 of companion to psychiatric studies

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10. Acute intermittent porphyria can lead to hallucinations.

TRUE

Clinical Medicine - Kumar & Clark.

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17. Prominent cortical atrophy is seen in Wilson's disease.

FALSE

Subcortical (OTP)

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28. Narcolepsy is associated with sudden onset REM sleep.

TRUE (OTP)

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5. Hachinski score is used to differentiate between Alzheimer's disease & vascular dementia.

Not 100% certain but think this may be TRUE.

Seminars in Old age psychiatry (Gaskell) explains the Hachinski score and its components and says that a score over 6 is highly suggestive of vascular dementia. Also says it is incorporated into other old age scales and is not uncommonly used.

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9. Paraventricular 5HT (or histamine) nuclei are responsible for satiety

False

supraoptic, paraventricular are associaited with adh secretion and oxytocin

ventromedial nucleus is responsable for satiety

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11.

lewy bodies are present in 40% of dementias.

FALSE.

5-15%

(Pg 300, Companion to Psych studies, 6th Ed, Johnstone et al)

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29. SPET I123 IBZ is used to detect 5HT2 receptors

FALSE

Used for dopamine receptors

(Pg 455, Comp to Psych St, 6th Ed, Johnstone et al)

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30. Up to 5 cells/mm is normal in CSF

TRUE

(Pg 359 & 750,Oxford Handbook of Clinical Medicine)

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14 true. A proteome is a cell’s repertoire of proteins; it dictates the cell’s function. It is generated by translation, the process of converting the information in RNA molecules into proteins

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19. After a five year follow-up in penetrating head injury to the right cerebral cortex, there is strong evidence that apathy is a significant association true according to lishman ,refer to table9 page 181 3rd edition ::)

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15. White matter hyperintensities are most commonly periventricular 18. Leukoariosis is associated with cognitive decline

both true, lishman, page459-460, in MRI they are hyperintensities, in CT they are radiolucent

:-XLeukoariosis seen in 33% sdat

38%mixed dementia, 5 with multi infarct and 11% nondemented elderly

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Q21. Somnambulism is most likely to occur in stage III and IV sleep.

True according to Core psychiatry page 399.

Sleep walking is a common familial disease that occurs during non-REM (stage III and IV) sleep and is largely confined to childhood.

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12, tau proteins interfere with microtubule formation

false

tau is involved with maintaining the stability of microtubules (institute of molecular and cell biology web site)

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27) Introversion is thought to be due to excessve sympathetic lability.

False - Psychology 4th ed. Gross. p 616.

This refers to Neuroticism (N) as described by Eysenck. Extroversion/Introversion thought to be detemined by 'balance' of ascending reticular activating system (ARAS).

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