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Part II ISQ Club - Organic

41 posts in this topic

Part II ISQs on two topics will be posted twice a week. You are encouraged to post a reply in the thread, stating whether you think an ISQ is true or false and why (eg. a short explanation, with reference to the textbook you used). Please only deal with one ISQ in each post and include the question as the first line of your post. All ISQs are taken from previous posts by Forum members.

In a few days this ISQ Club thread will be moved to the Question Bank board. If you submit an answer, your status will be changed to 'Question Bank member' and you will be able to see the Question Bank board. Please allow up to 48 hours for this change to happen.

1. Proteomes are collections of proteins in a cell

2. Heterozygous autosomal dominance can lead to variable penetrance

3. SPET I123 [?] is used to detect benzodiazepine receptors

4. DHEA opposes the effects of cortisol

5. Insulin release by the pancreas reduces tyrosine/tryptophan

6. CNV is an EEG evoked potential

7. The CT scan is usually found to be normal in advanced CJD

8. In CJD, met/val polymorphism is seen at codon 129

9. Sympathetic nerve damage causes hyperaesthesia

10. In HIV, multinucleate cells are found in the brain

11. NMDA activation causes neurotoxicity

12. Left heart failure causes apnoea and insomnia

13. Orthopnea suggets cardiac neurosis

14. Cranial nerve IV palsy prevents the eye looking medially and downwards

15. Alexia without agraphia is due to ACA damage

16. Another question on alexia with agraphia

17. Nicotine increases attention in non-smokers

18. Lewy body spectrum disorder includes Parkinson's disease

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1. Proteomes are collections of proteins in a cell

TRUE

The proteome is the collection of proteins found in a particular cell type under a particular type of stimulation. It is very roughly the protein equivalent of the genome.

www.wordiq.com/cgi-bin/knowledge/ lookup.cgi?title=Proteomics

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2. Heterozygous autosomal dominance can lead to variable penetrance

TRUE

(Pg 222, Comp to Psych St, 6th Ed, Johnstone et al)

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3. SPET I123 [?] is used to detect benzodiazepine receptors

(Pg 455, Comp to Psych St, 6th Ed, Johnstone et al)

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4. DHEA opposes the effects of cortisol

TRUE

“The beneficial effect of DHEA administration in depressed patients might result from its sigma 1 receptor-mediated enhancement of noradrenaline and serotonin neurotransmission, antiglucocorticoid effects, and cognition enhancing effects”

van Broekhoven & Verkes.

Psychopharmacology (Berl). 2003 Jan;165(2):97-110. Epub 2002 Nov 06.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12420152&dopt=Abstract

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17. Nicotine increases attention in non-smokers

TRUE

(Pg 435, Synopsis of Psy, 8th Ed, Kaplan & Sadock)

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3. SPET I123 is used to detect benzodiazepine receptors

TRUE

pg 455 Table 16.6 Comp to Psych Studies

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6. CNV is an EEG evoked potential

TRUE

(Pg 142, Exam notes in Psych, Basic Sc, Malhi & Mitchell)

CNV = contingent negative variation. It is an evoked potential 'elicited by initially providing a priming stimulus & then one which requires a response...

CNV 'correlates to attention & motivation, and is therefore attenuated by lack of stimulation or drugs like barbiturates'

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9. Sympathetic nerve damage causes hyperaesthesia

TRUE

'Neuropathic Pain:

Implies damage to nervous tissue either as a primary injury or as a consequence of a disease process (e.g. diabetes). Neuropathic pain results from damage or compression of sensory (or possibly sympathetic) neurones that demonstrate dysfunctional  and spontaneous pain signalling'.

http://www.themediweb.net/glossary/glossaryhome.htm#n

“Nerve pain (neuropathic pain, neuralgia). Caused by pressure on or damage to nerves. Often associated with altered sensation or weakness. At first there may be increased sensation in the area of skin the nerve supplies. This is called hyperaesthesia…”

http://www.cancernet.co.uk/pain.htm

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10. In HIV, multinucleate cells are found in the brain

TRUE

(Pg 370, Synopsis of Psych, Kaplan & Sadock, 8th Ed)

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14. Cranial nerve IV palsy prevents the eye looking medially and downwards

TRUE

innervates superior oblique

(Pg 106, Exam Notes in Psych, Basic Sc, Malhi & Mitchell)

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11. NMDA activation causes neurotoxicity

TRUE

(Pg 59, Comp to Psych St, 6th Ed, Johnstone et al)

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18. Lewy body spectrum disorder includes Parkinson's disease

TRUE

(Pg 525, Companion to Psych Studies, Johnstone et al, 6th Ed)

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14. Cranial nerve IV palsy prevents the eye looking medially and downwards

TRUE

innervates superior oblique

(Pg 106, Exam Notes in Psych, Basic Sc, Malhi & Mitchell)

BUT IV nerve damage will not affect eye movements on the horizontal plane............. so does it prevent the eye deviating medially ?????

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Safer you're right. A CN IV palsy prevents the eye from looking downwards and outwards(laterally).Thanks for the site too.

Hats off to dk2004 for her amazing and dedicated contribution anyway! :D

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5. TRUE - left heart failure is a cause of sleep apnoea(according to Manchester 2003 notes)

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14. Cranial nerve IV palsy prevents the eye looking medially and downwards

I still think that it's true, 'cos

Superior oblique 'depresses the eye in adduction (i.e. medially)'

Inferior rectus 'depresses eye . Laterally rotates eye in adduction'

medial rectus 'adducts eye'

http://www.meddean.luc.edu/lumen/MedEd/GrossAnatomy/dissector/mml/so.htm

sup. oblique supplied by trochlear (IV)nerve

Lesion of IV nerve will prevent downward medial (adduction) gaze

Inferior rectus supplied by oculomotor nerve

Remember (LR6 SO4)3

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14. Cranial nerve IV palsy prevents the eye looking medially and downwards

TRUE

I agree with DK.

Superior Oblique Paralysis (Fourth Nerve) can cause extremely subtle diplopia, but which is, of course, most marked when the affected eye tries to follow the finger medially and downwards.

http://www.healthsci.utas.edu.au/medicine/teaching/boyd/book/ch11.html

CRANIAL NERVE IV PALSY

SIGNS AND SYMPTOMS

The patient will present with complaints of vertical diplopia, which is especially manifest as the patient tries to read. There may be an inability to look down and in.

http://www.revoptom.com/handbook/sect6d.htm

Safer's excellent site shows what happens when the nerves are working well.

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13. Orthopnea suggets cardiac neurosis

False.

Orthopnoea is a physical sign that is caused by heart failure. Cardicac neurosis is a functional illness that would not have such clear, objective symptomatology.

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