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the_ninth_sin

q 1. - Premenstrual dysphoria

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Which of the following has the best evidence of use in pre-menstrual dysphoria?

Options:

Progesterone

SSRIs

Vitamin B6

Bright light therapy

Oil of evening primrose

solving 1 by 1

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why not oil of primrose ?!?!??!

just a guess...no idea what it is though :lol:

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and just to answer my own question here;s the answer ,

Evening primrose oil: what's all the fuss about?

by Ms. Alyson Greenhalgh and Dr. Sara Kirk

What does evening primrose oil do?

Evening primrose oil is a nutritional supplement and a member of the essential fatty acid (EFA) group. There are two members of the group, the omega-3 and omega-6 fatty acids.

Evening primrose oil is rich in omega-6 fatty acids and one of these, gamma linolenic acid (GLA), has certain medicinal properties that may act as an anti-inflammatory for conditions such as [highlight]arthriti[/highlight]s, [highlight]eczem[/highlight]a, [highlight]high blood pressure [/highlight]or hypertension. Evening primrose oil is also [highlight]believed to help alleviate cramps associated with pre-menstrual symptoms[/highlight], though this has yet to be scientifically proven. Eating fatty fish such as tuna, mackerel, salmon and herring, and using safflower, sunflower and rapeseed oils in cooking is the first step to increasing your intake of these acids

:lol:

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It would be helpful to discuss past questions as exam is not too far away.

I would go for SSRI as they are well eatablished.

Estrogens are  helpful as well but not progestrones

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though im still not a ahundered percent convinced as to what the answer would be as bith primrose and ssri's are mentioned !!!

:D

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insane the question asks most evidence hence i think we can go for ssris unless u come up with more evidence for primrose

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I think ans is SSRI-which we prescribe for PMT and there is some evidence for it.

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Moderate depression in a man who has suffered from MI. Which antidepressant

Fluoxetine

Citalopram

Sertraline

Paroxetine

Imipramine

Think sertraline is the ans.But dont know the ref.

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insane the question asks most evidence hence i think we can go for ssris unless u come up with more evidence for primrose

well dude not to be fussy but of you read teh article i post a link for,,,,,there is evidence for primrose's efficacy also

:P

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i am not denying that insane but the key word is BEST evidence

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Hi Guys

I wonder if the answer here can be B6? 8-)

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Hi Guys

I wonder if the answer here can be B6? 8-)

reference?? links??

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The answer I took from the BNF section 9.6.2 Vitamin B Group :)

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Dont doubt SSRIs as the answer for the PMDD

I quote from Comprehensive textbook of Psychiatry - Sadock 2004, Pg 2319

'More than 50 methods for treating premenstrual dysphoric disorder have been proposed. The number of treatments reflect the lack of a single effective cure, although the data available for the SSRIs demonstrate the most consistent efficacy to date.'

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The answer for SSRI post MI is likely to be Sertraline, because

SADHART (Sertraline Antidepressant Heart Attack Randomized Trial) study is probably the only RDBPCT which has looked into this. It had a large sample size, and although the patients on antidpressants had better outcome from the depression point of view, he could not show a statistically significant difference from in the cardiovascular outcome. The incidence of severe cardiovascular adverse events (death, MI, congestive heart failure, angina, and stroke) was numerically greater in the placebo group (22.4%) compared with the sertraline group (14.5%). But this difference was not statistically different at the p = .05 level.

So Sertraline has the evidence I guess

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I do not know what is the roll of VIT B6 in depression?

Ans is sertaline

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